Journal
FEBS LETTERS
Volume 586, Issue 10, Pages 1488-1496Publisher
WILEY
DOI: 10.1016/j.febslet.2012.04.003
Keywords
Galactinol synthase; RFOs; myo-Inositol; GT8 family glycosyltransferase
Funding
- Department of Biotechnology (DBT)
- Department of Atomic Energy (DAE), Government of India
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Galactinol synthase (GolS), a GT8 family glycosyltransferase, synthesizes galactinol and raffinose series of oligosaccharides (RFOs). Identification and analysis of conserved domains in GTs among evolutionarily diverse taxa, structure prediction by homology modeling and determination of substrate binding pocket followed by phylogenetic analysis of GolS sequences establish presence of functional GolS predominantly in higher plants, fungi having the closest possible ancestral sequences. Evolutionary preference for a functional GolS expression in higher plants might have arisen in response to the need for galactinol and RFO synthesis to combat abiotic stress, in contrast to other organisms lacking functional GolS for such functions. (c) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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