Journal
FEBS LETTERS
Volume 586, Issue 9, Pages 1300-1305Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2012.03.032
Keywords
Ceramide kinase; Ceramide 1-phosphate; Sphingolipid; Obesity; MCP-1
Funding
- Ministry of Education, Culture, Sports, Science, and Technology, Japan [23780344]
- Grants-in-Aid for Scientific Research [23780344] Funding Source: KAKEN
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Ceramide kinase (CERK) is an enzyme that phosphorylates ceramide to produce ceramide 1-phosphate. Recently, evidence has emerged that CERK has a role in inflammatory signaling of immune cells. Since obesity is accompanied by chronic, low-grade inflammation, we examined whether CERK might be involved using CERK-null mice. We determined that CERK deficiency suppresses diet-induced increases in body weight, and improves glucose intolerance. Furthermore, we demonstrated that CERK deficiency attenuates MCP-1/CCR2 signaling in macrophages infiltrating the adipose tissue, resulting in the suppression of inflammation in adipocytes, which might otherwise lead to obesity and diabetes. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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