Journal
FEBS LETTERS
Volume 586, Issue 6, Pages 897-904Publisher
WILEY
DOI: 10.1016/j.febslet.2012.02.020
Keywords
miRNA; miR-20a; TNKS2; Cervical cancer; Migration; Invasion
Funding
- National Natural Science Foundation of China [30873017, 91029714, 31071191]
- Natural Science Foundation of Tianjin [08JCZDJC23300, 09JCZDJC17500]
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miR-20a is an important member of the miR-17-92 cluster, and its real function in cervical cancer cells is unknown. Our study demonstrated that miR-20a was upregulated in cervical cancer tissues. Overexpression of miR-20a in cervical cancer-derived cell lines, HeLa and C-33A, enhanced long-term cellular proliferation, migration and invasion, whereas inhibition of miR-20a suppressed those functions. We also confirmed that oncogenic TNKS2 is directly upregulated by miR-20a. Furthermore, suppression of TNKS2 expression could inhibit colony formation, migration and invasion of cervical cancer cells. Therefore, we concluded that miR-20a can promote migration and invasion of cervical cancer cells through the upregulation of TNKS2. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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