Journal
FEBS LETTERS
Volume 586, Issue 8, Pages 1245-1251Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2012.03.046
Keywords
Mitochondrial fusion; Replication; Concatemer; Zygote; Non-Mendelian inheritance; Saccharomyces cerevisiae
Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [23510237]
- CREST, JST
- Grants-in-Aid for Scientific Research [23510237] Funding Source: KAKEN
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In budding yeast, the mitochondrial DNA (mtDNA) replication pathway involving the homologous DNA pairing protein Mhr1 promotes mitochondrial allele segregation. Mitochondrial fusion facilitates the recombination-mediated replication pathway; however, the role of fission remains largely unknown. By monitoring mitochondrial allele segregation during zygotic division, we found that the absence of fission proteins Fis1 or Mdv1, but not Dnm1, resulted in increased initial homoplasmy levels and decreased mtDNA copy number. However, decreases in mtDNA copy number alone were not sufficient for rapid establishment of homoplasmy, suggesting that inhibiting the activities of certain fission proteins promotes homoplasmy by reducing the number of mtDNA segregation units. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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