Journal
FEBS LETTERS
Volume 586, Issue 19, Pages 3179-3186Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2012.06.032
Keywords
DOR; TP53inp2; Basal autophagy; Nucleo-cytoplasmic shuttle; Nucleolus
Funding
- MEC [SAF2008-03803]
- Generalitat de Catalunya [2009SGR915]
- CIBERDEM (Instituto de Salud Carlos III)
- INTERREG IV-B-SUDOE-FEDER (DIOMED) [SOE1/P1/E178]
- COST Action [BM0602]
- University of Barcelona
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DOR is a bi-functional protein that regulates transcription and enhances starvation-induced autophagy. While autophagy has been mostly described as a stress-response mechanism, cells also need autophagy to maintain homeostasis in basal conditions. However, the mechanisms regulating basal autophagy still remain unknown. Our results show that DOR acts in basal autophagy. Indeed, DOR already undergoes nucleo-cytoplasmic shuttling in basal conditions and, surprisingly, DOR exits continuously the nucleus and traverses the nucleolus. However, the nucleolus integrity is not essential for both DOR nucleo-cytoplasmic shuttling and DOR function on basal autophagy. Taken together, we propose that DOR exit from the nucleus is essential for basal autophagy stimulation even under nucleolus disruption. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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