Journal
FEBS LETTERS
Volume 586, Issue 19, Pages 3242-3248Publisher
WILEY-BLACKWELL
DOI: 10.1016/j.febslet.2012.06.044
Keywords
Sulfate assimilation; Signaling; microRNA; ATP sulfurylase; Arabidopsis thaliana
Funding
- British Biotechnology and Biological Sciences Research Council (BBSRC)
- BBSRC CASE studentship
- Plant Bioscience Ltd.
- European Commission [SIROCCO LSHG-CT-2006-037900]
- Natural Environment Research Council [NE/C508069/1] Funding Source: researchfish
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In plants, microRNAs play an important role in many regulatory circuits, including responses to environmental cues such as nutrient limitations. One such microRNA is miR395, which is strongly up-regulated by sulfate deficiency and targets two components of the sulfate uptake and assimilation pathway. Here we show that miR395 levels are affected by treatments with metabolites regulating sulfate assimilation. The precursor of cysteine, O-acetylserine, which accumulates during sulfate deficiency, causes increase in miR395 accumulation. Feeding plants with cysteine, which inhibits sulfate uptake and assimilation, induces miR395 levels while buthionine sulfoximine, an inhibitor of glutathione synthesis, lowers miR395 expression. Thus, miR395 is an integral part of the regulatory network of sulfate assimilation. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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