Journal
FEBS LETTERS
Volume 586, Issue 7, Pages 1014-1021Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2012.02.044
Keywords
MicroRNA-1; Endothelin-1; Heart; Gene expression
Funding
- National Natural Science Foundation of China [30800375, 81101634, 30670760, 30901470]
- Major State Basic Research Development Program of the People's Republic of China [2009CB521902]
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There is a close correlation between endothelin-1 (ET-1) and microRNA-1 (miRNA-1) expression in the heart, but whether ET-1 expression is regulated by miRNA-1 warrants further research. Our results revealed multiple clues suggesting that miRNA-1 may participate in inhibiting ET-1 gene expression. The inhibitory effect of miRNA-1 on recombinant luciferase reporter gene was mediated by the target sequence at the 127th nucleotide on ET-1 3'UTR. We further confirmed that miRNA-1 could inhibit endogenous ET-1 gene expression at the post-transcriptional level. Our study provides a new perspective on the regulatory mechanism of ET-1 gene. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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