Journal
FEBS LETTERS
Volume 585, Issue 10, Pages 1393-1399Publisher
WILEY
DOI: 10.1016/j.febslet.2011.02.038
Keywords
Circadian clock; Kinase; Phosphatase; Phosphorylation
Funding
- Deutsche Forschungsgemeinschaft [SFBs 618, 740]
- EU
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Posttranslational modifications of circadian oscillator components are crucial for the generation of circadian rhythms. Among those phosphorylation plays key roles ranging from regulating degradation, complex formation, subcellular localization and activity. Although most of the known clock proteins are phosphoproteins in vivo, a comprehensive view about the regulation of clock protein phosphorylation is still missing. Here, we review our current knowledge about the role of clock protein phosphorylation and its regulation by kinases and phosphatases in eukaryotes with a major focus on the mammalian circadian clock. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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