Journal
FEBS LETTERS
Volume 585, Issue 18, Pages 2786-2794Publisher
WILEY
DOI: 10.1016/j.febslet.2011.04.044
Keywords
DNA repair; DNA-damage tolerance; PCNA; Ubiquitination; TLS
Funding
- Capital Normal University [10531182313]
- Canadian Institutes of Health Research [MOP-93612]
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Living organisms not only repair DNA damage induced by environmental agents and endogenous cellular metabolites, but have also developed mechanisms to survive in the presence of otherwise lethal lesions. DNA-damage tolerance (DDT) is considered such a mechanism that resumes DNA synthesis in the presence of replication-blocking lesions. Recent studies revealed that DDT in budding yeast is achieved through sequential ubiquitination of DNA polymerase processivity factor, proliferating cell nuclear antigen (PCNA). It is generally believed that monoubiquitinated PCNA promotes translesion DNA synthesis, whereas polyubiquitinated PCNA mediates an error-free mode of lesion bypass. This review will discuss how ubiquitinated PCNA modulates different means of lesion bypass. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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