Journal
FEBS LETTERS
Volume 585, Issue 23, Pages 3806-3812Publisher
WILEY
DOI: 10.1016/j.febslet.2011.05.030
Keywords
T cell; Microglia; Astrocyte; Oligodendrocyte; Cytokine; Chemokine
Funding
- Danish Research Agency
- Multiple Sclerosis Society of Denmark
- NovoNordisk Foundation
- Lundbeck Foundation
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In autoimmune diseases of the central nervous system (CNS), innate glial cell responses play a key role in determining the outcome of leukocyte infiltration. Access of leukocytes is controlled via complex interactions with glial components of the blood-brain barrier that include angiotensin II receptors on astrocytes and immunoregulatory mediators such as Type I interferons which regulate cellular traffic. Myeloid cells at the blood-brain barrier present antigen to T cells and influence cytokine effector function. Myelin-specific T cells interact with microglia and promote differentiation of oligodendrocyte precursor cells in response to axonal injury. These innate responses offer potential targets for immunomodulatory therapy. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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