Journal
FEBS LETTERS
Volume 585, Issue 12, Pages 1796-1800Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2011.04.024
Keywords
DEPP; Forkhead box protein; Endothelial cell; Transcription factor
Funding
- National Natural Science Foundation of China [30700302, 81070678]
- Natural Science Foundation of Jiangsu Province [BK2010533]
- Qinglan Project
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DEPP was initially cloned from the human endometrial stromal cell cDNA library, but the transcriptional regulation of DEPP remains largely unknown. We demonstrate here that expression of DEPP is FoxO-dependent in human endothelial cells. Two functional FoxO-responsive elements are identified in the DEPP promoter. Hypoxia stimulates DEPP expression in the endothelial cell line EA. hy926. Hypoxia-induced upregulation of DEPP is dependent on FoxO expression. We conclude that DEPP is regulated at the level of transcription by FoxO in human vascular endothelial cells. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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