Journal
FEBS LETTERS
Volume 585, Issue 11, Pages 1657-1662Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2011.04.060
Keywords
Aging; Longevity; SIRT1; NAMPT; NAD biosynthesis; NAD World
Funding
- National Institute on Aging [AG02150]
- National Heart, Lung, and Blood Institute [HL097817]
- Ellison Medical Foundation
- Longer Life Foundation
- Diabetes Research and Training Center
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Many countries are facing social and economic problems due to increased elderly demographics. With these demands, it is now critical to understand the fundamental regulatory mechanism for aging and longevity in mammals. Our studies on the mammalian NAD-dependent deacetylase SIRT1 and nicotinamide phosphoribosyltransferase (NAMPT)-mediated systemic NAD biosynthesis led us to propose a comprehensive model for the systemic regulatory network connecting metabolism and aging, termed the NAD World. In this article, I will discuss the importance of SIRT1 and NAMPT-mediated NAD biosynthesis in the NAD World and the system dynamics of this hierarchical network for the connection between metabolism and aging. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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