Journal
FEBS LETTERS
Volume 585, Issue 5, Pages 797-802Publisher
WILEY
DOI: 10.1016/j.febslet.2011.02.005
Keywords
Zcf37; Regulator; White-opaque switching; Candida albicans
Funding
- Chinese National Natural Science Foundation [30830003, 30900032]
- MOST [2010CB912103]
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Candida albicans, the most prevalent human fungal pathogen, can switch stochastically between white and opaque phases. In this study, we identified Zcf37, a zinc finger protein, as a new regulator of white-opaque switching. Deletion of ZCF37 increased white-to-opaque switching frequency and stabilized the opaque state. Overexpression of ZCF37 promoted conversion of opaque cells to white phase, but needed existence of Efg1, a key regulator required for maintenance of the white state. Deletion of EFG1 abolished the effect of ectopically expressed Zcf37 on opaque-to-white switching, whereas ectopic expression of EFG1 promoted white cell formation without presence of Zcf37. Our results suggest that Zcf37 acts as an activator of white cell formation and a repressor of opaque state and functions upstream of Efg1. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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