Journal
FEBS LETTERS
Volume 585, Issue 4, Pages 606-612Publisher
WILEY
DOI: 10.1016/j.febslet.2011.01.028
Keywords
Claudin; Tight junction; Epithelial cells; Paracellular barrier; Cell adhesion; PSI-BLAST
Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT)
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Claudins (Cldn) are essential membrane proteins of tight junctions (TJs), which form the paracellular permselective barrier. They are produced by a multi-gene family of 24 reported members in mouse and human. Based on a comprehensive search combined with phylogenetic analyses, we identified three novel claudins (claudin-25, -26, and -27). Quantitative RT-PCR revealed that the three novel claudins were expressed in a tissue- and/or developmental stage-dependent manner. Claudins-25 and -26, but not claudin-27, were immunofluorescently localized to TJs when exogenously expressed in cultured MDCK and Eph epithelial cell lines. These findings expand the claudin family to include at least 27 members. Structured summary: Claudin-25 and ZO-1 colocalize by fluorescence microscopy (View interaction) ZO-1 and Claudin-26 colocalize by fluorescence microscopy (View interaction) (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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