Journal
FEBS LETTERS
Volume 585, Issue 11, Pages 1663-1672Publisher
WILEY
DOI: 10.1016/j.febslet.2011.05.014
Keywords
ILK; PINCH; Parvin; Rac; Mammary epithelial; Differentiation
Funding
- Wellcome Trust
Ask authors/readers for more resources
Differentiation into tissue-specific cell types occurs in response to numerous external signals. Integrins impart signals from the extracellular matrix microenvironment that are required for cell differentiation. However, the precise cytoplasmic transducers of these signals are yet to be understood properly. In lactating mammary epithelial cells, integrin-linked kinase has been identified as an indispensable integrin-signalling adaptor that enables the activation of Rac1, which is necessary for prolactin-induced milk protein expression. Here we use examples from various tissues to summarise possible mechanisms by which ILK and its binding partners PINCH and Parvin (ILK-PINCH-Parvin complex) could be required for Rac activation and mammary epithelial differentiation. (C) 2011 Published by Elsevier B. V. on behalf of the Federation of European Biochemical Societies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available