Journal
FEBS LETTERS
Volume 585, Issue 15, Pages 2493-2500Publisher
WILEY
DOI: 10.1016/j.febslet.2011.06.031
Keywords
miR-15a; Cyclin T2; Cell differentiation; Spermatogenesis; MicroRNA microarray
Funding
- National Important Research Plan of China [2011CB944302]
- Ministry of Science and Technology of China
- State Key Laboratory Special fund [2060204]
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MicroRNAs (miRNAs) are posttranscriptional modulators of gene expression that play important roles in various biological processes. Spermatogenesis is a highly regulated process in which diploid spermatogonia eventually differentiate into haploid spermatozoa. In this study, we identified four differentially expressed miRNAs between two premeiotic male germ cells, made predictions about their putative targets, and confirmed cyclin T2 (Ccnt2) as a direct target of miR-15a. We also report that miR-15a inhibited muscle differentiation at least in part by targeting Ccnt2, which represents a novel interaction. Subsequently, miR-15a and Ccnt2 were profiled in developing mice testes to observe their inverse correlations in the postnatal 3-week period to understand their roles in spermatogenesis. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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