Journal
FEBS LETTERS
Volume 585, Issue 4, Pages 630-634Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2011.01.020
Keywords
Molecular shield; Protein homeostasis; Proteostasis; Desiccation tolerance; Anhydrobiosis; Cold tolerance
Funding
- Broodbank Trust
- European Research Council [233232]
- National Natural Science Foundation of China [30670180, NSFC-RS 30811130217]
- European Research Council (ERC) [233232] Funding Source: European Research Council (ERC)
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LEA (late embryogenesis abundant) proteins are intrinsically disordered proteins that contribute to stress tolerance in plants and invertebrates. Here we show that, when both plant and animal LEA proteins are co-expressed in mammalian cells with self-aggregating polyglutamine (polyQ) proteins, they reduce aggregation in a time-dependent fashion, showing more protection at early time points. A similar effect was also observed in vitro, where recombinant LEA proteins were able to slow the rate of polyQ aggregation, but not abolish it altogether. Thus, LEA proteins act as kinetic stabilisers of aggregating proteins, a novel function in protein homeostasis consistent with a proposed role as molecular shields. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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