Related references
Note: Only part of the references are listed.PCL2 modulates gene regulatory networks controlling self-renewal and commitment in embryonic stem cells
Emily Walker et al.
CELL CYCLE (2011)
EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair
Elena Ezhkova et al.
GENES & DEVELOPMENT (2011)
The Polycomb complex PRC2 and its mark in life
Raphael Margueron et al.
NATURE (2011)
Histone code pathway involving H3 S28 phosphorylation and K27 acetylation activates transcription and antagonizes polycomb silencing
Priscilla Nga Ieng Lau et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
PRC2 Complexes with JARID2, MTF2, and esPRC2p48 in ES Cells to Modulate ES Cell Pluripotency and Somatic Cell Reprograming
Zhuo Zhang et al.
STEM CELLS (2011)
Cancer-Related Epigenome Changes Associated with Reprogramming to Induced Pluripotent Stem Cells
Joyce E. Ohm et al.
CANCER RESEARCH (2010)
The Bmi-1 polycomb protein antagonizes the (-)-epigallocatechin-3-gallate-dependent suppression of skin cancer cell survival
Sivaprakasam Balasubramanian et al.
CARCINOGENESIS (2010)
A Region of the Human HOXD Cluster that Confers Polycomb-Group Responsiveness
Caroline J. Woo et al.
CELL (2010)
The Long Noncoding RNA, Jpx, Is a Molecular Switch for X Chromosome Inactivation
Di Tian et al.
CELL (2010)
Induction of pluripotency in human endothelial cells resets epigenetic profile on genome scale
Maria A. Lagarkova et al.
CELL CYCLE (2010)
TNF/p38α/Polycomb Signaling to Pax7 Locus in Satellite Cells Links Inflammation to the Epigenetic Control of Muscle Regeneration
Daniela Palacios et al.
CELL STEM CELL (2010)
Polycomb-like 2 Associates with PRC2 and Regulates Transcriptional Networks during Mouse Embryonic Stem Cell Self-Renewal and Differentiation
Emily Walker et al.
CELL STEM CELL (2010)
ESCs Require PRC2 to Direct the Successful Reprogramming of Differentiated Cells toward Pluripotency
Carlos F. Pereira et al.
CELL STEM CELL (2010)
The DUBle Life of Polycomb Complexes
Bernd Schuettengruber et al.
DEVELOPMENTAL CELL (2010)
Interpretation of Developmental Signaling at Chromatin: The Polycomb Perspective
Ritwick Sawarkar et al.
DEVELOPMENTAL CELL (2010)
UTX mediates demethylation of H3K27me3 at muscle-specific genes during myogenesis
Shayesta Seenundun et al.
EMBO JOURNAL (2010)
Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA
Syuzo Kaneko et al.
GENES & DEVELOPMENT (2010)
Jarid2 and PRC2, partners in regulating gene expression
Gang Li et al.
GENES & DEVELOPMENT (2010)
Polycomb complexes act redundantly to repress genomic repeats and genes
Martin Leeb et al.
GENES & DEVELOPMENT (2010)
Bmi-1 Reduction Plays a Key Role in Physiological and Premature Aging of Primary Human Keratinocytes
Sonia Cordisco et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2010)
Polycomb Group Protein Displacement and Gene Activation through MSK-Dependent H3K27me3S28 Phosphorylation
Simmi Suman Gehani et al.
MOLECULAR CELL (2010)
Short RNAs Are Transcribed from Repressed Polycomb Target Genes and Interact with Polycomb Repressive Complex-2
Aditi Kanhere et al.
MOLECULAR CELL (2010)
Ring1B Compacts Chromatin Structure and Represses Gene Expression Independent of Histone Ubiquitination
Ragnhild Eskeland et al.
MOLECULAR CELL (2010)
Genome-wide Identification of Polycomb-Associated RNAs by RIP-seq
Jing Zhao et al.
MOLECULAR CELL (2010)
Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells
Matthias Stadtfeld et al.
NATURE (2010)
Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB
Johanna C. Scheuermann et al.
NATURE (2010)
JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells
Diego Pasini et al.
NATURE (2010)
Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
Rajnish A. Gupta et al.
NATURE (2010)
Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators
David Landeira et al.
NATURE CELL BIOLOGY (2010)
Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex
Joao D. Pereira et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Dnmt3a-Dependent Nonpromoter DNA Methylation Facilitates Transcription of Neurogenic Genes
Hao Wu et al.
SCIENCE (2010)
Polycomb group protein-mediated repression of transcription
Lluis Morey et al.
TRENDS IN BIOCHEMICAL SCIENCES (2010)
GC-Rich Sequence Elements Recruit PRC2 in Mammalian ES Cells
Eric M. Mendenhall et al.
PLOS GENETICS (2010)
Targeted Overexpression of EZH2 in the Mammary Gland Disrupts Ductal Morphogenesis and Causes Epithelial Hyperplasia
Xin Li et al.
AMERICAN JOURNAL OF PATHOLOGY (2009)
Ezh2 Orchestrates Gene Expression for the Stepwise Differentiation of Tissue-Specific Stem Cells
Elena Ezhkova et al.
CELL (2009)
Jarid2/Jumonji Coordinates Control of PRC2 Enzymatic Activity and Target Gene Occupancy in Pluripotent Cells
Jamy C. Peng et al.
CELL (2009)
Jumonji Modulates Polycomb Activity and Self-Renewal versus Differentiation of Stem Cells
Xiaohua Shen et al.
CELL (2009)
A Vertebrate Polycomb Response Element Governs Segmentation of the Posterior Hindbrain
Angela Sing et al.
CELL (2009)
Chromatin Signatures in Multipotent Human Hematopoietic Stem Cells Indicate the Fate of Bivalent Genes during Differentiation
Kairong Cui et al.
CELL STEM CELL (2009)
MicroRNA control of muscle development and disease
Andrew H. Williams et al.
CURRENT OPINION IN CELL BIOLOGY (2009)
Developmental roles of the histone lysine demethylases
Amanda Nottke et al.
DEVELOPMENT (2009)
Recruitment of Polycomb group complexes and their role in the dynamic regulation of cell fate choice
Bernd Schuettengruber et al.
DEVELOPMENT (2009)
Epigenetic reprogramming during wound healing: loss of polycomb-mediated silencing may enable upregulation of repair genes
Tanya Shaw et al.
EMBO REPORTS (2009)
Modifications of RNA polymerase II are pivotal in regulating gene expression states
Emily Brookes et al.
EMBO REPORTS (2009)
Lessons from X-chromosome inactivation: long ncRNA as guides and tethers to the epigenome
Jeannie T. Lee
GENES & DEVELOPMENT (2009)
Reversine Increases the Plasticity of Lineage-committed Cells toward Neuroectodermal Lineage
Eun Kyung Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
p38-γ-dependent gene silencing restricts entry into the myogenic differentiation program
Mark A. Gillespie et al.
JOURNAL OF CELL BIOLOGY (2009)
Polycomb Group Protein Enhancer of Zeste 2 Is an Oncogene That Promotes the Neoplastic Transformation of a Benign Prostatic Epithelial Cell Line
Breanne D. W. Karanikolas et al.
MOLECULAR CANCER RESEARCH (2009)
Mir-214-Dependent Regulation of the Polycomb Protein Ezh2 in Skeletal Muscle and Embryonic Stem Cells
Aster H. Juan et al.
MOLECULAR CELL (2009)
Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells
Daniel A. Lim et al.
NATURE (2009)
Mechanisms of Polycomb gene silencing: knowns and unknowns
Jeffrey A. Simon et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)
Polycomb Limits the Neurogenic Competence of Neural Precursor Cells to Promote Astrogenic Fate Transition
Yusuke Hirabayashi et al.
NEURON (2009)
Gene Regulation and Epigenetic Remodeling in Murine Embryonic Stem Cells by c-Myc
Chin-Hsing Lin et al.
PLOS ONE (2009)
Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression
Ahmad M. Khalil et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Maintenance of Undifferentiated State and Self-Renewal of Embryonic Neural Stem Cells by Polycomb Protein Ring1B
Monica Roman-Trufero et al.
STEM CELLS (2009)
Polycomb group complexes - many combinations, many functions
Tom K. Kerppola
TRENDS IN CELL BIOLOGY (2009)
H2AZ Is Enriched at Polycomb Complex Target Genes in ES Cells and Is Necessary for Lineage Commitment
Menno P. Creyghton et al.
CELL (2008)
Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency
Jacob Hanna et al.
CELL (2008)
Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3K4/K27 trimethylation
Shaun D. Fouse et al.
CELL STEM CELL (2008)
Stem cell regulation by polycomb repressors: postponing commitment
Alexandra M. Pietersen et al.
CURRENT OPINION IN CELL BIOLOGY (2008)
Mechanisms involved in the regulation of histone lysine demethylases
Fei Lan et al.
CURRENT OPINION IN CELL BIOLOGY (2008)
Polycomb Group Proteins Ezh2 and Rnf2 Direct Genomic Contraction and Imprinted Repression in Early Mouse Embryos
Rrni Terranova et al.
DEVELOPMENTAL CELL (2008)
Dnm3os, a Non-Coding RNA, Is Required for Normal Growth and Skeletal Development in Mice
Tokumitsu Watanabe et al.
DEVELOPMENTAL DYNAMICS (2008)
Control of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3
George L. Sen et al.
GENES & DEVELOPMENT (2008)
Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease
Paul A. C. Cloos et al.
GENES & DEVELOPMENT (2008)
MicroRNA-26a targets the histone methyltransferase Enhancer of Zeste homolog 2 during myogenesis
Chung Fai Wong et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Expression of Bmi-1 in epidermis enhances cell survival by altering cell cycle regulatory protein expression and inhibiting apoptosis
Kathy Lee et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2008)
Reversine, a novel Aurora kinases inhibitor, inhibits colony formation of human acute myeloid leukemia cells
Anna Morena D'Alise et al.
MOLECULAR CANCER THERAPEUTICS (2008)
Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors
Fabio Mohn et al.
MOLECULAR CELL (2008)
Kcnq1ot1 Antisense Noncoding RNA Mediates Lineage-Specific Transcriptional Silencing through Chromatin-Level Regulation
Radha Raman Pandey et al.
MOLECULAR CELL (2008)
Ezh1 and Ezh2 Maintain Repressive Chromatin through Different Mechanisms
Raphael Margueron et al.
MOLECULAR CELL (2008)
EZH1 Mediates Methylation on Histone H3 Lysine 27 and Complements EZH2 in Maintaining Stem Cell Identity and Executing Pluripotency
Xiaohua Shen et al.
MOLECULAR CELL (2008)
Dissecting direct reprogramming through integrative genomic analysis
Tarjei S. Mikkelsen et al.
NATURE (2008)
The Bmi-1 polycomb group gene in skin cancer: regulation of function by (-)-epigallocatechin-3-gallate
Sivaprakasam Balasubramanian et al.
NUTRITION REVIEWS (2008)
The Histone H3 Lysine 27-Specific Demethylase Jmjd3 Is Required for Neural Commitment
Thomas Burgold et al.
PLOS ONE (2008)
Frequent switching of Polycomb repressive marks and DNA hypermethylation in the PC3 prostate cancer cell line
Einav Nili Gal-Yam et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Polycomb Proteins Targeted by a Short Repeat RNA to the Mouse X Chromosome
Jing Zhao et al.
SCIENCE (2008)
Differentiation of Neural Stem Cells into Oligodendrocytes: Involvement of the Polycomb Group Protein Ezh2
Falak Sher et al.
STEM CELLS (2008)
Polycomb repressive complex 2 is dispensable for maintenance of embryonic stem cell pluripotency
Stormy J. Chamberlain et al.
STEM CELLS (2008)
Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains
Manching Ku et al.
PLOS GENETICS (2008)
RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo
Julia Zeitlinger et al.
NATURE GENETICS (2007)
Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells
Julie K. Stock et al.
NATURE CELL BIOLOGY (2007)
p38 MAPK signaling regulates recruitment of Ash2L-containing methyltransferase complexes to specific genes during differentiation
Shravanti Rampalli et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2007)
RNA polymerase is poised for activation across the genome
Ginger W. Muse et al.
NATURE GENETICS (2007)
SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron
Kristen Jepsen et al.
NATURE (2007)
UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development
Karl Agger et al.
NATURE (2007)
H3K27 demethylases, at long last
Tomek Swigut et al.
CELL (2007)
Polycomb response elements mediate the formation of chromosome higher-order structures in the bithorax complex
Chiara Lanzuolo et al.
NATURE CELL BIOLOGY (2007)
Whole-genome mapping of histone H3 Lys4 and 27 trimethylations reveals distinct genomic compartments in human embryonic stem cells
Xiao Dong Zhao et al.
CELL STEM CELL (2007)
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
Tarjei S. Mikkelsen et al.
NATURE (2007)
A chromatin landmark and transcription initiation at most promoters in human cells
Matthew G. Guenther et al.
CELL (2007)
Functional demarcation of active and silent chromatin domains in human HOX loci by Noncoding RNAs
John L. Rinn et al.
CELL (2007)
High-resolution profiling of histone methylations in the human genome
Artern Barski et al.
CELL (2007)
The polycomb group protein Suz12 is required for embryonic stem cell differentiation
Diego Pasini et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Interplay of IKK/NF-κB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy
Swarnali Acharyya et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells
Adrian P. Bracken et al.
GENES & DEVELOPMENT (2007)
Genome regulation by polycomb and trithorax proteins
Bernd Schuettengruber et al.
CELL (2007)
Scratching the surface of skin development
Elaine Fuchs
NATURE (2007)
Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer
Yeshayahu Schlesinger et al.
NATURE GENETICS (2007)
Expression of BMI-1 in normal skin and inflammatory and neoplastic skin lesions
Christina M. Reinisch et al.
JOURNAL OF CUTANEOUS PATHOLOGY (2007)
Biology of polycomb and trithorax group proteins
Achim Breiling et al.
INTERNATIONAL REVIEW OF CYTOLOGY - A SURVEY OF CELL BIOLOGY, VOL 258 (2007)
Concise review: Roles of polycomb group proteins in development and disease: A stem cell perspective
Vinagolu K. Rajasekhar et al.
STEM CELLS (2007)
NF-kappa B regulation of YY1 inhibits skeletal myogenesis through transcriptional silencing of myofibrillar genes
Huating Wang et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Whole-genome analysis of histone H3 lysine 4 and lysine 27 methylation in human embryonic stem cells
Guangjin Pan et al.
CELL STEM CELL (2007)
Implication of polycomb members Bmi-1, Mel-18, and Hpc-2 in the regulation of p16INK4a, p14ARF, h-TERT, and c-Myc expression in primary breast carcinomas
Javier Silva et al.
CLINICAL CANCER RESEARCH (2006)
Reversine-treated fibroblasts acquire myogenic competence in vitro and in regenerating skeletal muscle
Luigi Anastasia et al.
CELL DEATH AND DIFFERENTIATION (2006)
Polycomb silencers control cell fate, development and cancer
Anke Sparmann et al.
NATURE REVIEWS CANCER (2006)
The genomic landscape of histone modifications in human T cells
Tae-Young Roh et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
p16INK4A is a robust in vivo biomarker of cellular aging in human skin
Sigrun Ressler et al.
AGING CELL (2006)
Signaling meets chromatin during tissue regeneration in Drosophila
Cedric Maurange et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2006)
Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex
Zhizhong Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing
Stefan Schoeftner et al.
EMBO JOURNAL (2006)
Genome-wide analysis of Polycomb targets in Drosophila melanogaster
Yuri B. Schwartz et al.
NATURE GENETICS (2006)
Polycomb complexes repress developmental regulators in murine embryonic stem cells
LA Boyer et al.
NATURE (2006)
Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions
AP Bracken et al.
GENES & DEVELOPMENT (2006)
Chromatin signatures of pluripotent cell lines
V Azuara et al.
NATURE CELL BIOLOGY (2006)
A Polycomb group protein complex with sequence-specific DNA-binding and selective methyl-lysine-binding activities
T Klymenko et al.
GENES & DEVELOPMENT (2006)
A bivalent chromatin structure marks key developmental genes in embryonic stem cells
BE Bernstein et al.
CELL (2006)
Control of developmental regulator's by polycomb in human embryonic stem cells
TI Lee et al.
CELL (2006)
The epigenetic network regulating muscle development and regeneration
D Palacios et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2006)
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells
YH Loh et al.
NATURE GENETICS (2006)
The polycomb group gene Ezh2 prevents hematopoietic stem cell exhaustion
LM Kamminga et al.
BLOOD (2006)
The Polycomb group protein EZH2 directly controls DNA methylation
E Viré et al.
NATURE (2006)
Skeletal muscle specification by myogenin and Mef2D via the SWI/SNF ATPase Brg1
Y Ohkawa et al.
EMBO JOURNAL (2006)
The role of polycomb group proteins in cell cycle regulation during development
Anne-Marie Martinez et al.
CELL CYCLE (2006)
Suppression of Polycomb group proteins by JNK signalling induces transdetermination in Drosophila imaginal discs
N Lee et al.
NATURE (2005)
Tissue-specific TAFs counteract polycomb to turn on terminal differentiation
X Chen et al.
SCIENCE (2005)
Mechanisms underlying the transcriptional regulation of skeletal myogenesis
V Sartorelli et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2005)
Delving into the diversity of facultative heterochromatin: the epigenetics of the inactive X chromosome
E Heard
CURRENT OPINION IN GENETICS & DEVELOPMENT (2005)
Core transcriptional regulatory circuitry in human embryonic stem cells
LA Boyer et al.
CELL (2005)
Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells
CA Cowan et al.
SCIENCE (2005)
DNA methylation and human disease
KD Robertson
NATURE REVIEWS GENETICS (2005)
Regulation of cellular plasticity in Drosophila imaginal disc cells by the polycomb group, trithorax group and lama genes
A Klebes et al.
DEVELOPMENT (2005)
Polycomb group protein Ezh2 controls actin polymerization and cell signaling
I Su et al.
CELL (2005)
p38 MAPK-induced nuclear factor-κB activity is required for skeletal muscle differentiation:: Role of interleukin-6
B Baeza-Raja et al.
MOLECULAR BIOLOGY OF THE CELL (2004)
Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas
C Leung et al.
NATURE (2004)
Dedifferentiation of lineage-committed cells by a small molecule
SB Chen et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)
p38 pathway targets SWI-SNF chromatin-remodeling complex to muscle-specific loci
C Simone et al.
NATURE GENETICS (2004)
Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1
A Iwama et al.
IMMUNITY (2004)
The Polycomb EA2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation
G Caretti et al.
GENES & DEVELOPMENT (2004)
Epigenetic regulation of cellular memory by the polycomb and trithorax group proteins
L Ringrose et al.
ANNUAL REVIEW OF GENETICS (2004)
Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity
D Pasini et al.
EMBO JOURNAL (2004)
A MyoD-generated feed-forward circuit temporally patterns gene expression during skeletal muscle differentiation
BH Penn et al.
GENES & DEVELOPMENT (2004)
Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation
AV Molofsky et al.
NATURE (2003)
EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells
CG Kleer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Genome imprinting regulated by the mouse Polycomb group protein Eed
J Mager et al.
NATURE GENETICS (2003)
Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition
JW Voncken et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
The polycomb group protein EZH2 is involved in progression of prostate cancer
S Varambally et al.
NATURE (2002)
General transcription factors bind promoters repressed by Polycomb group proteins
A Breiling et al.
NATURE (2001)
The Polycomb-group gene Ezh2 is required for early mouse development
D O'Carroll et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Dedifferentiation of mammalian myotubes induced by msx1
SJ Odelberg et al.
CELL (2000)
p38 and extracellular signal-regulated kinases regulate the myogenic program at multiple steps
ZG Wu et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
Share Paper
