Journal
FEBS LETTERS
Volume 585, Issue 20, Pages 3263-3269Publisher
WILEY
DOI: 10.1016/j.febslet.2011.08.052
Keywords
miRNA; miRNA-1; FN1; Migration; Invasion; HEp2
Funding
- National Natural Science Foundation of China [30873017, 31071191, 91029714]
- Natural Science Foundation of Tianjin [08JCZDJC23300, 09JCZDJC17500]
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MicroRNAs (miRNAs) are an evolutionarily conserved class of endogenous, non-coding RNAs that modulate gene expression at the post-transcriptional level and are involved in tumorigenesis. In this study, we demonstrate that miR-1 suppresses the potential for growth, migration and invasion in the HEp2 cell line. Furthermore, we validate that FN1 is a direct target gene for miR-1 via fluorescent reporter assay and is negatively regulated by miR-1. Moreover, the knockdown of FN1 has the same phenotypic effects as the overexpression of miR-1. Taken together, our results provide evidence that miR-1 may play a role as a tumor suppressor gene in laryngeal carcinoma. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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