Journal
FEBS LETTERS
Volume 585, Issue 12, Pages 1923-1928Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2011.04.074
Keywords
RecQ; DNA repair; Double-strand break; Anaphase bridge; Nucleus; Drosophila melanogaster
Funding
- Promotion and Mutual Aid Corporation for Private Schools of Japan
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Drosophila melanogaster RecQ5, a member of the RecQ family, is expressed in early embryos. The loss of maternally-derived RecQ5 leads to spontaneous mitotic defects in syncytial embryos. We demonstrate that the mitotic defects are derived from anaphase DNA bridges. Pairs of daughter nuclei that had been linked by the bridges concurrently exited from the cycle and were eliminated by Chk2-dependent centrosome inactivation. These results suggest that the lack of RecQ5 leads to spontaneous double-stranded DNA breaks (DSBs). RecQ5 may function in the resolution of anaphase DNA bridges during mitosis or in DSB repair during interphase in syncytial Drosophila embryos. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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