Journal
FEBS LETTERS
Volume 585, Issue 3, Pages 567-573Publisher
WILEY
DOI: 10.1016/j.febslet.2011.01.010
Keywords
microRNA-146a; oxLDL; Dendritic cell; CD40L; Immuno-inflammation
Funding
- Zhejiang Provincial Natural Science Foundation of China [Y2100372]
- National Natural Science Foundation of China [30370570/C03030201, 30670866/C03030201]
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There is increasing evidence that microRNAs (miRNAs) play important roles in cell proliferation, apoptosis and differentiation that accompany inflammatory responses. However, whether miRNAs are associated with dendritic cell (DC) immuno-inflammatory responses to oxidized low density lipoprotein (oxLDL) stimulation is yet unknown. Our study aims to explore the link of miRNA to lipid-overload and the immuno-inflammatory mechanism for atherosclerosis. Human primary monocyte-derived DCs were transfected with miR-146a mimics and inhibitor, and then stimulated by oxLDL. For the flow cytometric analysis of the DC immunophenotype, supernatants were collected to determine inflammatory chemokine markers. Our study clearly revealed that miRNA-146a regulates the maturation process and pro-inflammatory cytokine secretion in DCs by targeting CD40L in ox-LDL-stimulated DCs. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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