Journal
FEBS LETTERS
Volume 585, Issue 4, Pages 693-699Publisher
WILEY
DOI: 10.1016/j.febslet.2011.01.033
Keywords
MicroRNA; Evi1; Colon cancer; RNA interference
Funding
- Doris Duke Charitable Foundation
- Lifespan/Tufts/Brown CFAR's Retrovirology Services Laboratory [NIHP30AI042853]
- Center for Cancer Research Development [NIHP20RR017695]
- Center for Stem Cell Biology [P20RR018757]
- National Institutes of Health [T32DA013911]
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MicroRNA profiling of diseased/non-diseased tissue has identified expression signatures associated with a wide range of pathogenic conditions including malignancy. For example, colon cancer is associated with the under expression of miRNA-143 yet the molecular etiology of under expression is unknown. The K-Ras oncogene is a target of miRNA-143. Here, we show that the ecotropic viral integration site 1 oncoprotein (Evi1) is a transcriptional suppressor of the miRNA-143 gene. We find an indirect relationship between miRNA-143 and Evi1 expression. A complex molecular axis linking Evi1, miRNA-143 is operational in human colon cancer. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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