Journal
FEBS LETTERS
Volume 585, Issue 22, Pages 3544-3548Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2011.10.017
Keywords
Calcium signalling; NAADP; CD38; Jurkat T lymphocyte
Funding
- Deutsche Forschungsgemeinschaft [GU 360/7-5, GU 360/15-1]
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The role of the multifunctional enzyme CD38 in formation of the Ca(2+)-mobilizing second messenger nicotinic acid adenine dinucleotide phosphate (NAADP) was investigated. Gene silencing of CD38 did neither inhibit NAADP synthesis in intact Jurkat T cells nor in thymus or spleen obtained from CD38 knock out mice. In vitro, both NAADP formation by base-exchange and degradation to 2-phospho adenosine diphosphoribose were efficiently decreased. Thus in vivo CD38 appears to be a NAADP degrading rather than a NAADP forming enzyme, perhaps avoiding desensitizing NAADP levels in intact cells. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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