Journal
FEBS LETTERS
Volume 585, Issue 24, Pages 3969-3977Publisher
WILEY
DOI: 10.1016/j.febslet.2011.11.004
Keywords
Anticancer; DNA; G-quadruplex; Human telomere; Fluorescence
Funding
- Singapore Biomedical Research Council [07/1/22/19/542]
- Ministry of Education [ARC30/07, RG62/07]
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We characterized and compared the fluorescence properties of various well-defined G-quadruplex structures. The increase of intrinsic fluorescence of G-rich DNA sequences when they form G-quadruplexes can be used to monitor the folding and unfolding of G-quadruplexes as a function of cations and temperature. The temperature-dependent fluorescence spectra of different G-quadruplexes also exhibit characteristic patterns. Thus, the stability and possibly also the structure of G-quadruplexes can be characterized and distinguished by their intrinsic fluorescence spectra. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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