Journal
FEBS LETTERS
Volume 585, Issue 14, Pages 2377-2384Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2011.06.011
Keywords
Leucine-rich repeat protein; Monocytes/macrophages; Cell migration; Actin cytoskeleton reorganization
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Leucine-rich repeat and fibronectin type III domain-containing (LRFN) family proteins are thought to be neuronal-specific proteins that play essential roles in neurite outgrowth and synapse formation. Here, we focused on expression and function of LRFN4, the fourth member of the LRFN family, in non-neural tissues. We found that LRFN4 was expressed in a wide variety of cancer and leukemia cell lines. We also found that expression of LRFN4 in the monocytic cell line THP-1 and in primary monocytes was upregulated following macrophage differentiation. Furthermore, we demonstrated that LRFN4 signaling regulated both the transendothelial migration of THP-1 cells and the elongation of THP-1 cells via actin cytoskeleton reorganization. Our data indicate that LRFN4 signaling plays an important role in the migration of monocytes/macrophages. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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