Journal
FEBS LETTERS
Volume 584, Issue 9, Pages 1793-1799Publisher
WILEY
DOI: 10.1016/j.febslet.2010.02.049
Keywords
Voltage-dependent anion-selective channel; Mitochondria; Plasma membrane; NADH-oxidoreductase; Dynamic membrane protein redistribution
Funding
- University of Catania
- FIRB RBRN07BMCT
- PRIN MIUR [2008SW44CS_004]
- Department of Biochemistry and Molecular Biology, Monash University
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Voltage-dependent anion channels (VDACs) have originally been characterized as mitochondrial porins. Starting in the late 1980s, however, evidence began to accumulate that VDACs can also be expressed in plasma membranes. In this review, we briefly revisit the historical milestones in the discovery of plasma membrane-bound VDAC, and we critically analyze the evidence for VDAC plasma membrane localization obtained from various purification strategies and recently from plasma membrane proteomics studies. We discuss the possible biological function and relevance of VDAC in the plasma membrane and finally discuss a hypothetical model of how VDAC may be targeted to the plasma membrane. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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