Journal
FEBS LETTERS
Volume 584, Issue 7, Pages 1359-1366Publisher
WILEY
DOI: 10.1016/j.febslet.2010.02.013
Keywords
Aminopeptidase I; Cytoplasm to vacuole targeting; Selective autophagy
Funding
- NIGMS NIH HHS [R01 GM053396-20, R01 GM053396] Funding Source: Medline
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Autophagy is a highly conserved, ubiquitous process that is responsible for the degradation of cytosolic components in response to starvation. Autophagy is generally considered to be non-selective; however, there are selective types of autophagy that use receptor and adaptor proteins to specifically isolate a cargo. One type of selective autophagy in yeast is the cytoplasm to vacuole targeting (Cvt) pathway. The Cvt pathway is responsible for the delivery of the hydrolase aminopeptidase I to the vacuole; as such, it is the only known biosynthetic pathway that utilizes the core machinery of autophagy. Nonetheless, it serves as a model for the study of selective autophagy in other organisms. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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