Journal
FEBS LETTERS
Volume 584, Issue 16, Pages 3519-3524Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2010.07.018
Keywords
Apoptosis; Autophagy; Beclin 1; Survivin; Tumor necrosis factor-related apoptosis-inducing ligand
Funding
- National Cancer Institute [R01CA 135038, R01CA 66077]
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We reported a novel interaction between Beclin 1, a key regulator of autophagy, and survivin, a member of the inhibitor of apoptosis protein family. We found that knock-down of Beclin 1 down-regulated survivin protein, and the turnover rate of survivin was increased when Beclin 1 expression was silenced. Knock-down of Beclin 1 sensitized glioma cells to TRAIL-induced apoptosis, and introduction of survivin antagonized the sensitizing effect, suggesting that down-regulation of survivin mediates the enhanced sensitivity to TRAIL-induced apoptosis. These results demonstrate a novel interaction between Beclin 1 and survivin, and may provide a potential mechanism underlying the cross-talk between autophagy and apoptosis.
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