Journal
FEBS LETTERS
Volume 584, Issue 7, Pages 1302-1312Publisher
WILEY
DOI: 10.1016/j.febslet.2010.01.011
Keywords
Autophagy; Phosphoinositide; Signalling; Endoplasmic reticulum; PI 3-Kinase
Funding
- Biotechnology and Biological Sciences Research Council (BBSRC)
- Biotechnology and Biological Sciences Research Council [BBS/E/B/00001221] Funding Source: researchfish
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The simple phosphoinositide phosphatidylinositol 3-phosphate (PI(3)P) has been known to have important functions in endocytic and phagocytic traffic, and to be required for the autophagic pathway. In all of these settings, PI(3)P appears to create platforms that serve to recruit specific effectors for membrane trafficking events. In autophagy, PI(3)P may form the platform for autophagosome biogenesis. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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