Journal
FEBS LETTERS
Volume 584, Issue 17, Pages 3773-3778Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2010.06.016
Keywords
Telomere; Shelterin; DNA damage response; NHEJ
Funding
- NIA NIH HHS [R01 AG028888] Funding Source: Medline
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The linear nature of eukaryotic chromosomes leaves natural DNA ends susceptible to triggering DNA damage responses. Telomeres are specialized nucleoprotein structures that comprise the end zone of chromosomes. Besides having specialized sequences and structures, there are six resident proteins at telomeres that play prominent roles in protecting chromosome ends. In this review, we discuss this team of proteins, termed shelterin, and how it is involved in regulating DNA damage signaling, repair and replication at telomeres. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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