Journal
FEBS LETTERS
Volume 584, Issue 7, Pages 1296-1301Publisher
WILEY
DOI: 10.1016/j.febslet.2010.02.061
Keywords
Autophagy; Membrane biogenesis; Endoplasmic reticulum; Beclin-1; Atg14p
Funding
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- Takeda Science Foundation, Japan
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Autophagosomes (APs) are unique organelles that enwrap cytoplasmic components when necessary. APs then fuse with lysosomes and enclosed materials are degraded. Although approximately 30 autophagy-related genes (ATG) required for AP formation have been identified, fundamental questions on the membrane source or dynamics during the formation remain unresolved. Here, we present a comprehensive overview of the putative membrane sources identified to date. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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