Journal
FEBS LETTERS
Volume 584, Issue 12, Pages 2618-2625Publisher
WILEY
DOI: 10.1016/j.febslet.2010.03.017
Keywords
Checkpoint; DNA repair; Apoptosis; XPA; Cryptochrome; Chemotherapy
Funding
- NIEHS NIH HHS [P30 ES010126] Funding Source: Medline
- NIGMS NIH HHS [R01 GM031082-23A2, R01 GM031082, R01 GM032833-21, R01 GM032833] Funding Source: Medline
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Mammalian cells possess a cell-autonomous molecular clock which controls the timing of many biochemical reactions and hence the cellular response to environmental stimuli including genotoxic stress. The clock consists of an autoregulatory transcription-translation feedback loop made up of four genes/proteins, BMal1, Clock, Cryptochrome, and Period. The circadian clock has an intrinsic period of about 24 h, and it dictates the rates of many biochemical reactions as a function of the time of the day. Recently, it has become apparent that the circadian clock plays an important role in determining the strengths of cellular responses to DNA damage including repair, checkpoints, and apoptosis. These new insights are expected to guide development of novel mechanism-based chemotherapeutic regimens. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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