Journal
FEBS LETTERS
Volume 584, Issue 17, Pages 3779-3784Publisher
WILEY
DOI: 10.1016/j.febslet.2010.05.024
Keywords
Pot1; Telomere; ACD; Telomerase; TEBP
Funding
- NIH [GM088728, GM041803]
- Stowers Institute
- Pew Charitable Trusts
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Proteins that specifically bind the single-stranded overhang at the ends of telomeres have been identified in a wide range of eukaryotes and play pivotal roles in chromosome end protection and telomere length regulation. Here we summarize recent findings regarding the functions of POT1 proteins in vertebrates and discuss the functional evolution of POT1 proteins following gene duplication in protozoa, plants, nematodes and mice. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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