Journal
FEBS LETTERS
Volume 584, Issue 17, Pages 3682-3695Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2010.07.029
Keywords
MRN complex; DNA damage; DNA repair; DSB; Telomere
Funding
- National Institutes of Health [AI067952, CA097093, AI051686]
- Salk Institute
- Ruth L. Kirschstein National Research Service Award [NIH/NCI T32 CA009523]
- H.A. & Mary K. Chapman Charitable Trust
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Genomes are subject to constant threat by damaging agents that generate DNA double-strand breaks (DSBs). The ends of linear chromosomes need to be protected from DNA damage recognition and end-joining, and this is achieved through protein-DNA complexes known as telomeres. The Mre11-Rad50-Nbs1 (MRN) complex plays important roles in detection and signaling of DSBs, as well as the repair pathways of homologous recombination (HR) and non-homologous end-joining (NHEJ). In addition, MRN associates with telomeres and contributes to their maintenance. Here, we provide an overview of MRN functions at DSBs, and examine its roles in telomere maintenance and dysfunction. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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