Journal
FEBS LETTERS
Volume 584, Issue 10, Pages 1975-1981Publisher
WILEY
DOI: 10.1016/j.febslet.2010.04.017
Keywords
Mitochondria; Calcium handling; Calcium channel; Mitochondrial calcium uniporter; Ryanodine receptor
Funding
- Deutsche Forschungsgemeinschaft
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Mitochondrial Ca2+ handling plays an important role in energy production and various cellular signaling processes. Mitochondrial Ca2+ uptake is regulated by the mitochondrial Ca2+ uniporter (MCU), at least one non- MCU Ca2+ channel and possibly a mitochondrial ryanodine receptor. Two distinct mechanisms mediate Ca2+ outward transport, the Na+-dependent (mNCX) and the Na+-independent Ca2+ efflux. In recent years we gained more insight into the regulation and function of these different Ca2+ transport mechanisms. However, the precise physiological role and the molecular structure of all mitochondrial Ca2+ transporters and channels still has to be determined. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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