Journal
FEBS LETTERS
Volume 584, Issue 10, Pages 1948-1955Publisher
WILEY
DOI: 10.1016/j.febslet.2010.01.032
Keywords
Ca2+ channel; Mitochondrial Ca2+ uniporter (MCU); Mitochondrial ryanodine receptor (mRyR); Rapid mode Ca2+ uptake (RaM); Ruthenium red; Ru360; Ryanodine
Funding
- NIH [HL-33333, AR44657, GM57249]
- American Heart Association [0525951T]
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Ca2+ channels that underlie mitochondrial Ca2+ transport first reported decades ago have now just recently been precisely characterized electrophysiologically. Numerous data indicate that mitochondrial Ca2+ uptake via these channels regulates multiple intracellular processes by shaping cytosolic and mitochondrial Ca2+ transients, as well as altering the cellular metabolic and redox state. On the other hand, mitochondrial Ca2+ overload also initiates a cascade of events that leads to cell death. Thus, characterization of mitochondrial Ca2+ channels is central to a comprehensive understanding of cell signaling. Here, we discuss recent progresses in the biophysical and electrophysiological characterization of several distinct mitochondrial Ca2+ channels. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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