Journal
FEBS LETTERS
Volume 584, Issue 10, Pages 2049-2056Publisher
WILEY
DOI: 10.1016/j.febslet.2010.01.038
Keywords
Potassium channel; Kv1.3; Mitochondria; Apoptosis; Pro-apoptotic Bax
Funding
- Italian Association for Cancer Research [5118]
- European Molecular Biology Organization
- Progetti di Rilevante Interesse Nazionale
- DFG [Gu 335/13- 3]
- International Association for Cancer Research
- Cassa di Risparmio di Padova e Rovigo
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Recent evidence points to the crucial involvement of voltage-gated potassium channels (Kv) in apoptotic volume decrease and in the regulation of apoptosis in several systems. We have recently described the presence of a Kv channel, Kv1.3, in the mitochondria of lymphocytes. Expression of the channel correlated with increased sensitivity to apoptotic stimuli. Mitochondrial Kv1.3 contributes to the apoptotic cascade in T lymphocytes by interacting with pro-apoptotic Bax resulting in alteration of mitochondrial functional parameters and ultimately, in cytochrome c release. The present review summarizes the current understanding of the function of Kv channels in apoptosis in several cell types as well as the role of mitochondrial Kv1.3 in the regulation of cell death in lymphocytes. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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