Journal
FEBS LETTERS
Volume 584, Issue 7, Pages 1342-1349Publisher
WILEY
DOI: 10.1016/j.febslet.2010.01.006
Keywords
Autophagy-related gene 1; Unc-51 like kinase 1; Vps34; Jun-N-terminal kinase; Target of rapamycin
Funding
- NIGMS NIH HHS [R01 GM062509-09, R01 GM062509] Funding Source: Medline
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Drosophila has been shown to be a powerful model to study autophagy, whose regulation involves a core machinery consisting of Atg proteins and upstream signaling regulators similar to those in yeast and mammals. The conserved role in degrading proteins and organelles gives autophagy an important function in coordinating several cellular processes as well as in a number of pathological conditions. This review summarizes key studies in Drosophila autophagy research and discusses potential questions that may lead to better understanding of the roles and regulation of autophagy in higher eukaryotes. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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