Journal
FEBS LETTERS
Volume 584, Issue 24, Pages 4910-4914Publisher
WILEY
DOI: 10.1016/j.febslet.2010.09.042
Keywords
Ikaros; Transcription factors; B-Cell development; Pre-B cell receptor; Cell cycle progression
Funding
- Leukaemia and Lymphoma Research (LLR)
- Medical Research Council, UK
- Medical Research Council [MC_U120027516] Funding Source: researchfish
- MRC [MC_U120027516] Funding Source: UKRI
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Ikaros is the founding member of a family of transcription factors. Ikaros proteins are required for the normal development of lymphocytes and other blood cell lineages, and have an important role in haematopoietic malignancies. Accumulating data link Ikaros to immune receptor rearrangement and signaling, and the balance between proliferation and differentiation of immune cells. The emerging picture is that Ikaros family members are critical for a functional immune system that confers protection against invading pathogens, while minimising the risk of leukaemic transformation, immune pathology, and autoimmunity. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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