Journal
FEBS LETTERS
Volume 584, Issue 24, Pages 4845-4850Publisher
WILEY
DOI: 10.1016/j.febslet.2010.09.001
Keywords
T cell receptor; Immunological synapse; Actin; Microtubules; Ezrin; Ezrin-radixin-moesin
Funding
- Association pour la Recherche sur le Cancer (ARC)
- Ligue Contre le Cancer
- Agence National de Recherche (ANR)
- Agence National de Recherche sur la SIDA (ANRS)
- Institut Pasteur
- CNRS
Ask authors/readers for more resources
T cell antigen receptor signaling is triggered and controlled in specialized cellular interfaces formed between T cells and antigen-presenting cells named immunological synapses. Both microtubules and actin cytoskeleton rearrange at the immunological synapse in response to T cell receptor triggering, ensuring in turn the accuracy of intracellular signaling. Recent reports show that the crosstalk between the cortical actin cytoskeleton and microtubule networks is key for structuring the immunological synapse and for controlling T cell receptor signaling. Immunological synapse architecture and the interaction between the signaling machinery and various cytoskeletal elements are therefore crucial for the fine-tuning of T cell signaling. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available