Journal
FEBS LETTERS
Volume 584, Issue 24, Pages 4933-4940Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2010.08.006
Keywords
Mast cell; Fc epsilon RI signal transduction; Syk; Fyn; Gab2; Phosphatase
Funding
- National Institutes of Health, NIDCR
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The aggregation by antigen of the IgE bound to its high affinity receptor on mast cells initiates a complex series of biochemical events that result in the release of inflammatory mediators. The essential role of the protein tyrosine kinase Syk has been appreciated for some time, and newer results have defined the mechanism of its activation. The use of siRNA has defined the relative contribution of Syk, Fyn and Gab2 to signaling and has made possible a screening study to identify previously unrecognized molecules that are involved in these pathways. Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
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