Journal
FEBS LETTERS
Volume 584, Issue 8, Pages 1437-1442Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2010.03.014
Keywords
Mitochondria; Uncoupling protein 2; Reactive oxygen species; Inflammation; Immune response
Funding
- OncoSuisse [OCS-02260-08-2008]
- European Commission [LSHM-CT-2003-503041]
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Uncoupling protein 2 (UCP2) belongs to the family of mitochondrial carriers. Here, we highlight recent findings regarding UCP2 function in the immune system. UCP2 controls immune cell activation by modulating MAPK pathways and the production of mitochondrial reactive oxygen species. In several models of infection, inflammation and autoimmunity, a regulatory impact of UCP2 was demonstrated by its direct implication in the production of cytokines and nitric oxide and in cell migration. In addition, UCP2 is reported as a key protein for oxidation of fatty acids, glutamine and glucose. Therefore we present a model of how the regulation of nutrient oxidation by UCP2 promotes immune cell activation. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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