Journal
FEBS LETTERS
Volume 584, Issue 23, Pages 4751-4755Publisher
WILEY
DOI: 10.1016/j.febslet.2010.10.051
Keywords
Siderophore; Efflux pump; Metal trafficking; Iron transport; Secretion; Pseudomonas aeruginosa
Funding
- Centre National de la Recherche Scientifique (CNRS)
- ANR (Agence Nationale de la Recherche [ANR-08-BLAN-0315-01]
- French Ministere de la Recherche et de la Technologie
- Agence Nationale de la Recherche (ANR) [ANR-08-BLAN-0315] Funding Source: Agence Nationale de la Recherche (ANR)
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Pseudomonas aeruginosa secretes the fluorescent siderophore, pyoverdine (PVD), to enable iron acquisition. Epifluorescence microscopy and cellular fractionation were used to investigate the role of an efflux pump, PvdRT-OpmQ, in PVD secretion. Bacteria lacking this efflux pump accumulated PVD, or a fluorescent precursor, in the periplasm, due to their inability to efficiently secrete into the media newly synthesized PVD. PvdRT-OpmQ is only the second system identified for secretion of newly synthesized siderophores by Gram negative bacteria. (c) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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