Journal
FEBS LETTERS
Volume 584, Issue 20, Pages 4361-4365Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2010.09.038
Keywords
hnRNP K; Herpesvirus; HSV-1; Replication; Egress; Virus-host
Funding
- Forschungsausschuss of the Universitat des Saarlandes, Saarbrucken, Germany
- Baygene and LMUexcellent
- MRC [G0501453] Funding Source: UKRI
- Medical Research Council [G0501453] Funding Source: researchfish
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The heterogeneous nuclear ribonucleoprotein (hnRNP) K is an evolutionarily conserved protein with roles in signal transduction and gene expression. An impact of hnRNP K on the life cycle of a broad range of viral pathogens was reported while functional data for herpesviruses were lacking. In this study we show that hnRNP K is important for Herpes simplex virus 1 egress. In absence of hnRNP K, viral entry, gene expression, viral DNA replication, and maturation of nuclear particles appear normal whereas release of infectious virions to the extracellular space was significantly affected. Our results indicate that hnRNP K has an impact on a late step of herpesviral propagation making it a potential antiviral target. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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