Journal
FEBS LETTERS
Volume 584, Issue 7, Pages 1411-1416Publisher
WILEY
DOI: 10.1016/j.febslet.2010.01.056
Keywords
Autophagy; Skeletal muscle; Atrophy; Protein degradation; Muscle wasting; Akt
Funding
- ASI
- Telethon-Italy [TCP04009]
- European Union [223576]
- AFM [14135]
- Italian Ministry of Education, University and Research
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Muscle mass represents 40-50% of the human body and, in mammals, is one of the most important sites for the control of metabolism. Moreover, during catabolic conditions, muscle proteins are mobilized to sustain gluconeogenesis in the liver and to provide alternative energy substrates for organs. However, excessive protein degradation in the skeletal muscle is detrimental for the economy of the body and it can lead to death. The ubiquitin-proteasome and autophagy-lysosome systems are the major proteolytic pathways of the cell and are coordinately activated in atrophying muscles. However, the role and regulation of the autophagic pathway in skeletal muscle is still largely unknown. This review will focus on autophagy and discuss its beneficial or detrimental role for the maintenance of muscle mass. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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