Journal
FEBS LETTERS
Volume 584, Issue 8, Pages 1481-1486Publisher
WILEY
DOI: 10.1016/j.febslet.2010.02.063
Keywords
MiR-155; MyD88; Inflammation; Helicobacter pylori
Funding
- Chinese National Natural Science Foundation [30770113]
- National Basic Research Program of China [2009CB522606]
- National High Technology Research and Development Program of China [2006AA02A208]
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MicroRNA-155 (miR-155) has been implicated as a central regulator of the immune system. We have previously reported that miR-155 negatively regulates Helicobacter pylori (H. pylori)-induced inflammation, but the molecular mechanism of miR-155 regulating the inflammation is not fully clear. Here, we identified myeloid differentiation protein 88 (MyD88) as a target gene of miR-155, and found that miR-155 decreased MyD88 expression at the protein but not the mRNA message level, suggesting that the miR-155-mediated inhibition is a post-transcriptional event. Furthermore, the overexpression of miR-155 led to significantly reduced IL-8 production induced by H. pylori infection. Thus, we have demonstrated that miR-155 can negatively regulate inflammation by targeting a key adaptor molecule MyD88 in inflammatory pathways. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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