Journal
FEBS LETTERS
Volume 584, Issue 15, Pages 3402-3409Publisher
WILEY
DOI: 10.1016/j.febslet.2010.06.036
Keywords
Mitochondria; ATP; Hematopoietic stem cell; Progenitor; Hematopoiesis
Funding
- Japan Society for Promotion of Science (JSPS) [19100007]
- Grants-in-Aid for Scientific Research [22650091, 19100007] Funding Source: KAKEN
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Mitochondrial energy production is involved in various cellular processes. Here we show that ATP content is significantly increased in lineage-restricted progenitor cells compared with hematopoietic stem and progenitor cells (HSPCs) or more differentiated cells. Transplantation analysis using a mouse model of mitochondrial disease revealed that mitochondrial respiration defects resulted in a significant decrease in the total number and repopulating activity of bone marrow cells, although the number of HSPCs increased. The proliferative activity of HSPCs and lineage-restricted progenitor cells was not impaired by reduction of ATP content and there seems to be no associated increase in reactive oxygen species levels and apoptosis. Our findings indicate that mitochondrial respiration defects modulate HSPC commitment/differentiation into lineage-restricted progenitor cells. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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