Journal
FEBS LETTERS
Volume 585, Issue 7, Pages 981-985Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2010.12.025
Keywords
Polarity; Metabolism; Cancer; LKB1; AMPK; Myosin II
Funding
- CNRS/INSERM
- Association Pour la recherche sur le Cancer (ARC)
- Ligue Nationale for Research against Cancer
- Association for Research on Cancer
- Canceropole Lyon-Rhone Alpes Auvergne (CLARA)
- ANR
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The LKB1 tumor suppressor kinase is an activator of the AMP-activated protein kinase (AMPK), a metabolic gauge that responds to variations of cellular energetic levels by favoring catabolic versus anabolic processes. Recent studies have provided substantial evidence that LKB1 and AMPK control cell polarity from invertebrates to mammals. This review examines how the LKB1-AMPK pathway, in conjunction with other positional signals, converts energy-sensing information into the activation of Myosin II to maintain epithelial-cell architecture but also to complete cell division. This molecular link between polarity and metabolism may constitute an ancient stress-response protective mechanism that was co-opted for tumor suppression during evolution. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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