Journal
FEBS LETTERS
Volume 584, Issue 12, Pages 2548-2555Publisher
WILEY
DOI: 10.1016/j.febslet.2010.03.050
Keywords
Blood-group antigen recognition; Cholera toxin; Climate change/global warming; Protein-carbohydrate interaction; Structural biology; Vaccine development
Funding
- Norwegian Research Council [171631/V40, 183613/S10]
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Climate change has the potential to increase the threat of water-borne diseases, through rises in temperature and sea-level, and precipitation variability. Cholera poses a particular threat, and the need to develop better intervention tools is imminent. Cholera infections are particularly severe for blood group O individuals, who are less protected by the current vaccines. Here we derive a hypothesis as to the molecular origins of blood-group dependence of this disease, based on relevant epidemiological, clinical and molecular data, and give suggestions on how to plan prevention strategies, and develop novel and improved pharmaceuticals. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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