Journal
FEBS LETTERS
Volume 584, Issue 12, Pages 2681-2688Publisher
WILEY
DOI: 10.1016/j.febslet.2010.04.056
Keywords
T cell; Cyclic adenosine monophosphate; T cell receptor; C-terminal Src kinase; Ezrin
Funding
- Functional Genomics Programme
- Research Council of Norway
- Norwegian Cancer Society
- Novo Nordic Foundation
Ask authors/readers for more resources
A variety of immunoregulatory signals to effector T cells from monocytes, macrophages and regulatory T cells act through cyclic adenosine monophosphate. In the effector T cell, the protein kinase A (PKA) type I isoenzyme localizes to lipid rafts during T cell activation and modulates directly the proximal events that take place after engagement of the T cell receptor. The most proximal target for PKA phosphorylation is C-terminal Src kinase (Csk), which initiates a negative signal pathway that fine-tunes the T cell activation process. The A kinase anchoring protein Ezrin colocalizes PKA and Csk by forming a supramolecular signaling complex consisting of PKA, Ezrin, Ezrin/radixin/moesin (ERM) binding protein of 50 kDa (EBP50), phosphoprotein associated with glycosphingolipid-enriched membrane microdomains (GEMs) (PAG) and Csk. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available